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SEROMYCIN (CYCLOSERINE): USE IN SPECIAL POPULATIONS
Pregnancy Category C.
Because Cycloserine (Seromycin) crosses the placenta and data are limited regarding safety of the drug in pregnant women, ATS, CDC, and IDSA state the drug should be used for treatment of TB during pregnancy only when there are no suitable alternatives.
Seromycin (Cycloserine) is distributed into milk. Discontinue nursing or the drug.
Safety and efficacy not established in children.
ATS, CDC, IDSA, and AAP consider cycloserine one of several second-line antituberculosis agents that can be used in children.
Caution in patients with alcohol-related hepatitis.
Use caution in patients with renal impairment. Seromycin (Cycloserine) capsules are contraindicated in those with severe renal insufficiency.
Symptoms of acute toxicity may occur if usual dosage is used in patients with renal impairment. Adjust dosage according to the degree of renal impairment and serum cycloserine concentrations. Closely monitor patients with renal impairment for evidence of neurotoxicity.
Determine serum cycloserine concentrations at least once weekly in patients with reduced renal function; adjust dosage to maintain concentrations < 30 mcg/mL.
Seromycin (Cycloserine) related pharmaceutical drugs and medications
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|Aczone use in specific populations - Dapsone
||Gel; Topical; Dapsone 5%Gel; Topical; Dapsone 7.5%
|Iscotin - Isoniazid
||Tablets; Oral; Isoniazid 100 mg
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