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SEROMYCIN (CYCLOSERINE): PHARMACOKINETICS
Seromycin (Cycloserine) capsules 250 mg is readily absorbed from GI tract. About 65–90% of an oral dose absorbed; a peak plasma concentrations attained within 3–8 hours.
Plasma concentrations of 25–30 mcg/mL generally are maintained with a dosage of 250 mg twice daily, but relationship between plasma concentrations and dosage not always consistent.
Some drug accumulation may occur in patients with normal renal function during the first 3 days of cycloserine therapy.
Seromycin (Cycloserine) capsules is widely distributed into body tissues and fluids including the lungs, ascitic fluid, pleural fluid, lymph tissue, and synovial fluid in concentrations approximately equal to plasma concentrations of the drug. Also distributed into bile, sputum, and lymph tissue.
CSF concentrations are 50–80% of concurrent plasma concentrations in patients with uninflamed meninges and 80–100% of concurrent plasma concentrations in patients with inflamed meninges.
Cycloserine (Seromycin) is readily crosses the placenta and is distributed into amniotic fluid.
This medication is distributed into milk in concentrations similar to maternal plasma concentrations.
Plasma Protein Binding
Not bound to plasma proteins.
About 35% of a dose appears to be metabolized to unidentified metabolites.
60–70% of an oral dose excreted unchanged in urine by glomerular filtration within 72 hours. The maximum excretion rate occurs during the first 2–6 hours; approximately 50% of the dose is eliminated within 12 hours. Negligible amounts excreted in feces.
Cycloserine (Seromycin) is Removed by hemodialysis.
Approximately 10 hours in patients with normal renal function.
Half-life of Cycloserine (Seromycin) capsules is prolonged in patients with impaired renal function.
Seromycin (Cycloserine) related pharmaceutical drugs and medications
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