Buy Cycloserine (Seromycin) online

Buy Seromycin (Cycloserine) anti tuberculosis drug
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SEROMYCIN (CYCLOSERINE): CLINICAL PHARMACOLOGY

After oral administration, Seromycin (Cycloserine) is readily absorbed from the gastrointestinal tract, with peak blood levels occurring in 4 to 8 hours. Blood levels of 25 to 30 mcg/mL can generally be maintained with the usual dosage of 250 mg twice a day, although the relationship of plasma levels to dosage is not always consistent. Concentrations in the cerebrospinal fluid, pleural fluid, fetal blood, and mother's milk approach those found in the serum. Detectable amounts are found in ascitic fluid, bile, sputum, amniotic fluid, and lung and lymph tissues. Approximately 65 percent of a single dose of cycloserine can be recovered in the urine within 72 hours after oral administration. The remaining 35 percent is apparently metabolized to unknown substances. The maximum excretion rate occurs 2 to 6 hours after administration, with 50 percent of the drug eliminated in 12 hours.

Microbiology

Cycloserine inhibits cell–wall synthesis in susceptible strains of gram–positive and gram–negative bacteria and in Mycobacterium tuberculosis.

Susceptibility Tests

Seromycin (Cycloserine) clinical laboratory standard powder is available for both direct and indirect methods1 of determining the susceptibility of strains of mycobacteria. Cycloserine MICs for susceptible strains are 25 mcg/mL or lower.

Actions and Spectrum

  • May be bacteriostatic or bactericidal in action, depending on the concentration of the drug attained at the site of infection and the susceptibility of the infecting organism.
  • Inhibits cell wall synthesis in susceptible organisms by competing with D-Alanine for incorporation into the bacterial cell wall. In vitro, antibacterial activity may be inhibited by D-Alanine.
  • Spectrum of activity includes mycobacteria and some gram-positive and gram-negative bacteria.
  • Mycobacteria: Active against M. tuberculosis, M. bovis, and some strains of M. kansasii, M. marinum, M. ulcerans, M. avium complex (MAC), M. smegmatis, and M. intracellulare.
  • Gram-positive and gram-negative bacteria: Active against Staphylococcus aureus, Enterobacter, and Escherichia coli.
  • Natural and acquired resistance to cycloserine demonstrated in vitro and in vivo in strains of M. tuberculosis. No evidence of cross-resistance between cycloserine and other antituberculosis agents available in the USA.



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  • Allergan
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